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Both pregabalin and gabapentin are drugs prescribed to treat nerve pain, seizures, and anxiety disorders, but these two drugs are not the same. There are significant differences between the two, and it is important that you do not take medication that is not prescribed to you, even if the medication has been designed to treat the same conditions.
Here’s what you need to know when comparing pregabalin vs. gabapentin:
Pregabalin vs Gabapentin: What are They and How Do They Work?
Pregabalin and gabapentin are medications that are primarily prescribed in the treatment of nerve pain and seizure disorders. These drugs work by blocking certain brain signals that are responsible for pain perception. Pregabalin is a newer drug and is considered a stronger version of gabapentin, which means it works more efficiently at lower doses. However, these drugs have different chemical structures and are not suitable for all individuals.
Brand names of gabapentin include Horizant®, Gralise® and Neurontin®. Brand names of pregabalin include Lyrica® and Lyrica CR®.
What Conditions are Treated With Pregabalin and Gabapentin?
Pregabalin and gabapentin are both primarily used to treat nerve pain, seizures disorders, and related conditions, although they may also be used for off-label indications.
Conditions commonly treated with pregabalin [1]:
- Neuropathic pain associated with diabetic peripheral neuropathy
- Postherpetic neuralgia (nerve pain caused by shingles)
- Fibromyalgia
- Generalized anxiety disorder (GAD)
- Partial onset seizures in adults
Conditions commonly treated with gabapentin [2]:
- Neuropathic pain associated with diabetic peripheral neuropathy
- Postherpetic neuralgia
- Epilepsy (as adjunctive therapy for partial seizures)
Off-label uses of gabapentin include the treatment of Generalized anxiety disorder (GAD) and Fibromyalgia.
Are Pregabalin and Gabapentin Interchangeable?
Gabapentin and pregabalin are metabolized by the body in different ways. For those with liver or kidney conditions, it is important that proper precautions be taken. Before you take either of these medications, speak with your doctor if you have had any previous issues with your liver or kidneys.
Side Effect | Pregabalin | Gabapentin |
Dizziness | Yes | Yes |
Drowsiness | Yes | Yes |
Weight gain | Yes | Rare |
Edema (swelling) | Yes | Rare |
Dry mouth | Rare | Yes |
Headache | Yes | Yes |
Nausea | Yes | Yes |
Diarrhea | Yes | Yes |
Blurred vision | Yes | Yes |
Fatigue | Yes | Yes |
Cognitive impairment | Yes | Yes |
Tremors | Yes | Yes |
Mood changes | Yes | Yes |
Suicidal thoughts | Rare | Rare |
Allergic Reactions | Rare | Rare |
This is not a complete list of potential side effects of pregabalin vs. gabapentin. Every individual is different and may experience side effects that are not on this list. If you have been taking either of these drugs and are experiencing unexpected side effects, contact your medical provider.
Can You Get Addicted to Gabapentin and Pregabalin?
Both gabapentin and pregabalin have the potential to result in physical and psychological dependence. This risk increases significantly if these drugs are used in high doses or over long periods of time.
Individuals with a history of substance abuse disorders or addiction may be at an increased risk of developing dependence on these gabapentin and pregabalin.
Addiction Treatment for Gabapentin and Pregabalin
Addiction and substance abuse can happen to anyone. Whether you’ve been prescribed pregabalin or gabapentin or you’ve been taking it recreationally, it is possible to develop a substance dependence.
Frequently Asked Questions About Pregabalin vs. Gabapentin
Below, we have answered some of the most common questions we get about pregabalin vs. gabapentin
Can Gabapentin and Pregabalin be Used Together?
Pregabalin vs. Gabapentin: Medication Interactions
Medication | Gabapentin | Pregabalin |
Alcohol | Risk of central nervous system and respiratory depression | Risk of central nervous system and respiratory depression |
Antacids | Decreased absorption | No significant interaction |
Benzodiazepines | Risk of central nervous system and respiratory depression | Risk of central nervous system and respiratory depression |
Cimetidine | Increased plasma concentration | Increased plasma concentration |
Diuretics | No significant interaction | Increased risk of edema (swelling) |
Diabetes or high blood pressure medications | No significant interaction | Potential interaction |
Morphine | Increased sedation and dizziness | Risk of respiratory depression |
Naproxen | Increased risk of kidney damage | No significant interaction |
Hydrocodone | Risk of respiratory depression | No significant interaction |
Opioids | Risk of central nervous system and respiratory depression | Risk of central nervous system and respiratory depression |
Oxycodone | No significant interaction | Increased risk of respiratory depression |
Aceclofenac | Increased risk of kidney damage | No significant interaction |
Thiazolidinediones | No significant interaction | Increased risk of edema (swelling) and heart failure |
Important: This is not an exhaustive list of medication interactions. Speak with your doctor or pharmacist before taking pregabalin or gabapentin about any potential interactions.
Are Gabapentin and Pregabalin Safe When Pregnant or Breastfeeding?
Pregabalin vs. Gabapentin: Withdrawal Symptoms
Can You Drink Alcohol When Taking Pregabalin or Gabapentin?
How Do You Get Help for Someone Who is Abusing Pregabalin or Gabapentin?
If you or someone you know is abusing pregabalin or gabapentin, it is important to seek help as soon as possible. Abuse of these drugs can lead to severe health concerns and can even be fatal.
Contact a member of the Oceans Recovery team to learn more about your treatment options for gabapentin or pregabalin abuse.
Sources:
[1] Cross, A. (et al). National Center for Biotechnology Information. (2022, November 14th). Pregabalin. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK470341/ on 2023, April 10.[2] U.S. Food and Drug Administration. (2011, August 8). Neurontin® (gabapentin) Capsules, Neurontin® (gabapentin) Tablets, Neurontin® (gabapentin) Oral Solution. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020235s050,020882s035,021129s033lbl.pdf on 2023, April 10.
[3] Leek, J. Arif, H. National Center for Biotechnology Information. (2022, July 25). Pregnancy Medications. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK507858/ on 2023, April 10.